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Diagnostyka guzów z komórek tucznych u psów i kotów
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Wyszukaj w serwisie


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Diagnostyka guzów z komórek tucznych u psów i kotów


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Złotym standardem w diagnostyce guzów z komórek tucznych (MCT) jest badanie cytologiczne i histopatologiczne. Stopień zaawansowania klinicznego ustala się na podstawie obrazu klinicznego, uwzględniając stan węzłów chłonnych (cytologiczny/histologiczny). Z kolei dzięki dostępności badań immunohistologicznych oraz molekularnych możliwa jest ich dokładniejsza charakterystyka.

Cytologia jest wykorzystywana do diagnostyki przedoperacyjnej (ryc. 1) i oceny stopnia zaawansowania klinicznego (np. węzłów chłonnych, śledziony). Opublikowana klasyfikacja cytologiczna guzów komórek tucznych psów (Blackwood i wsp., 2012) ma ograniczenia, ponieważ cytologiczne kryteria złośliwości są często zawyżone, a podskórne MCT nie są identyfikowane.

WWP_9_24_przewodnik_Heike_Aupperle-Lellbach_DIAGNOSTYKA_GUZOW_KOMOREK_TUCZNYCH_RYC_1
Ryc. 1. Cytologia: słabo zróżnicowany guz komórek tucznych; ryc. Laboklin

Badanie histopatologiczne może być wykorzystane do rozróżnienia skórnych i podskórnych komórek tucznych oraz oceny marginesów resekcji. Klasyfikacja histologiczna umożliwia określenie biologicznego zachowania skórnych guzów komórek tucznych u psów (prawdopodobieństwo nawrotu, ryzyko przerzutów, czas przeżycia).

Istnieją dwa histopatologiczne systemy klasyfikacji skórnych guzów komórek tucznych u psów. Pierwszym jest starszy system klasyfikacji według Patnaika i wsp. (1984), który rozróżnia trzy stopnie guza:

  • stopień I dobrze zróżnicowany (ryc. 2),
  • stopień II umiarkowanie zróżnicowany,
  • stopień III słabo zróżnicowany.

WWP_9_24_przewodnik_Heike_Aupperle-Lellbach_DIAGNOSTYKA_GUZOW_KOMOREK_TUCZNYCH_RYC_2 [...]
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Mogą zainteresować Cię również


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Wizytówka firmy


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Sklep


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