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Które parametry chemii klinicznej mają sens u małych ssaków?
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Wyszukaj w serwisie


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Łatwa interpretacja wyników – które parametry chemii klinicznej mają sens u małych ssaków?


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Małe ssaki to zwierzęta, które dzieli się na uciekające i polujące. Poważne choroby muszą pozostać nierozpoznane przez długi czas – w przeciwnym razie zwierzęta mogłyby łatwo stać się ofiarami drapieżników. Diagnostyka laboratoryjna jest zatem ważną częścią procesu diagnostycznego, szczególnie w przypadku objawów, które niekoniecznie są specyficzne, np. apatia, brak apetytu i brak mobilności.

Wskazówką mogą być nie tylko zmiany w krwinkach czerwonych (niedokrwistość, odwodnienie) i białych (przesunięcie w lewo, chłoniak). Zmiany aktywności i stężenia parametrów biochemicznych (enzymów, substratów, elektrolitów) pokazują, które narządy są dotknięte lub jaki rodzaj zmian metabolicznych jest obecny. Najważniejsze parametry wymieniono w tab. 1.

WWP_10_24_przewodnik_Jana_Liebscher_PARAMETRY_CHEMII_KLINICZNEJ_U_MALYCH_SSAKOW_TAB_1 parametry
Tab. 1. Parametry kliniczno-chemiczne z przynależnością narządową/metaboliczną

Metabolizm wątroby

Enzymy: GLDH, ALT, AST, γ-GT (GGTP), AP oraz substraty: glukoza, albuminy, mocznik, bilirubina, trójglicerydy i kwasy żółciowe w surowicy są uważane za parametry wątrobowe u małych ssaków. Są one oznaczane w surowicy lub osoczu.

Dehydrogenaza glutaminianowa (GLDH) znajduje się w mitochondriach komórek wątroby, a także w komórkach serca i nerek (Wesche, 2014). Jest to najbardziej czuły enzym wątrobowy i reaguje nawet na łagodne uszkodzenie komórek (ostre hepatopatie z powodu anoreksji – magazynowania tłuszczu – i/lub zatrucia), jest dobrym markerem przy ostrych problemach z wątrobą w początkowej fazie rozwoju (Leban-Danzl et al., 2016). Oznaczenie poziomu [...]

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Mogą zainteresować Cię również


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Wizytówka firmy


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Sklep


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