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Nieodwzajemniona fascynacja – dlaczego glikokortykosteroidy w stanach nagłych nie zawsze spełniają nasze oczekiwania?
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Streszczenie
Glikokortykosteroidy endogenne są wytwarzane w korze nadnerczy i pełnią w organizmie wiele ważnych funkcji, oddziaływując wielokierunkowo na większość komórek organizmu. Syntetyczne glikokortykosteroidy wykorzystuje się m.in. w leczeniu: steroidozależnego zapalenia opon mózgowych i tętnic (SRMA), niedokrwistości hemolitycznej na tle immunologicznym (IMHA), przełomu nadnerczowego, astmy czy insulinomy. Niemniej jednak nierzadko podaje się je bez rzeczywistego uzasadnienia na zasadzie „prewencyjnej” czy też bazując na domniemanym działaniu, ignorując ich działania niepożądane i utrudniające postawienie ostatecznego rozpoznania.
Słowa kluczowe
glikokortykosteroidy, psy, koty, stany nagłe, intensywna terapia
Abstract
Endogenous glucocorticosteroids are produced by the adrenal cortex and are a key element of the adaptive, neurohormonal response to stress, i.e. sudden dysregulation of homeostasis such as acute inflammation, haemorrhage or trauma. Due to their anti-inflammatory and immunosuppressive activities synthetic glucocorticosteroids are recommended in the treatment of many emergencies in veterinary practice, including steroid responsive meningitis arteritis (SRMA), immune-mediated haemolytic anaemia (IMHA), asthma, Addisonian crisis or insulinoma to antagonize the peripheral effects of insulin. However, in many cases they are applied without any justification, using wrong protocol or a „preventative” or „speculative” treatment, ignoring their serious side effects and masking effects.
Keywords
glucocorticosteroids, dog, cat, emergency, critical [...]
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Mogą zainteresować Cię również
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POSTĘPOWANIA
w weterynarii
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